فهرست و منابع پایان نامه بررسی تأثیر درمان پریودنتال بر سطح سرمی C-reactive protein ، فیبرینوژن پلاسما و شمارش گلبول های سفید خون در مبتلایان به پریودنتیت
فهرست:
فصل اول : مقدمه و معرفی ................................................................................ 1
مقدمه ....................................................................................................................................................... 2
سلامت دهان و دندان و سلامت عمومی ............................................................................................ 3
بیماریهای پریودنتال ............................................................................................................................... 4
مارکرهای التهابی – CRP - ............................................................................................................. 7
پروتئین فیبرینوژن پلاسما ..................................................................................................................... 10
مکانیسم افزایش مارکرهای التهابی ..................................................................................................... 12
مارکرهای التهابی و بیماریهای سیستمیک ........................................................................................ 14
گلبولهای سفید خون ............................................................................................................................... 17
CRP و بیماری پریودنتال ................................................................................................................... 19
شستشوی (irrigation) بالای لثهای و زیر لثهای ......................................................................... 22
شستشوی پاکتها در مطب .......................................................................................... 22
کارآیی (efficacy) ..................................................................................................... 22
نتایج کلینیکی و میکروبیولوژیکی .................................................................................. 24
کاربرد موضعی مواد ضد میکروبی ................................................................................. 26
فصل دوم : مروری بر مقالات ............................................................................ 34
فصل سوم : روش تحقیق................................................................................... 48
اصول انتخاب بیماران ............................................................................................................................ 49
معاینات کلینیکی و پریودنتال ................................................................................................................ 50
روش درمان ............................................................................................................................................ 51
معاینات پاراکلینیکی و آزمایشگاهی ...................................................................................................... 52
محاسبه حجم نمونه، تعداد آن و تفسیر آماری دادهها ........................................................................ 53
فصل چهارم : نتایج ........................................................................................... 58
فصل پنجم : بحث ............................................................................................. 72
بحث ........................................................................................................................................................ 73
نتیجه گیری ............................................................................................................................................. 76
فهرست منابع ................................................................................................... 77
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منبع:
1) Aiuto F.D, Parker M. et al . periodontitis and systemic inflammation:
control of the local infection is associated with a reduction in serum
inflammatory markers. J dental Res. 2004; 83(2) : 156-60
2) D’Aiuto F, Ready D, et al . periodontal disease and CRP associated cardiovascular risk. J of perio Res . 2004 Aug; 39 (4) : 236
3) D’ Aiuto F, Nibali L, et al. short term effects of intensive periodontal therapy on serum inflammatory markers and cholesterol. J Dent Res. 2005; 87(3) : 269-73
4) Ajwan SH., et al . periodontal disease in eged population , and its role in cardiovascular Mortality. Arterioscler Thromb Vasc Biol 2004 Apr; 20: 1057-120
5) Ajwani SH., Mattila KJ , et al. Oral health status , CRP and mortality, a 10 years follow up study. Gerodontology . 2003 Jul; 20(1) : 32-40
6) Alibhai Z, Grossi SG, et al. Effect of periodontal therapy on systemic inflammatory mediators. Back to the periodontal Res. 2002 March.
7) Aunals of periodontology, 1996 world workshop in periodontics published by the AAP, vol:1, Nom: 1, 1996 Nov.
8) Bollen CML, mongardiniC. et al . The effect of a one-stage full-mouth disinfection on different intra oral niches. J of clin periodontology. 1998; 25:56-66.
9) Branuwald : Heart disease: A text book of cardiovascular medicine, 7th ed. W.B sunders company . 2005; chapter 36, 54.
10) Buhlin K, Gustafsson A, et al. Risk markers for atherosclerosis in adult, with sever periodontal disease Back to the periodontal Research – Diagnosis / epidemiology program (June 28-July 1, 2006)
11) Carranza FA, Newman MG. Clinical periodontology . 10th ed . 2006 W.B Sunders Co. Chapter: 9, 18, 52,55.
12) Cosyn J. wyn I, et al . subgingival chlorhexidine varnisk administration as on adjunct to same-day full mouth. Root planning . I: Clinical observations. J periodontal . 2007; 78 (3) : 430-37
13) Cosy J, wyn I, et al. subgingival chlorhexidine varnish administratin as an adjunct to same –day full mouth . root planning . II: Microbiological observations. J periodontal . 2007: 78(3): 438-45.
14) De maat MP, kluft C, et al. Determinants of CRP concentration in bload . Ital heart 2001; 2(3): 189-95
15) D. Rogers J, Lee R, et al. Association between Periodontal disease and CRP with a history of heart attack. J perio Res 1998; 33:212-300
16) Ebersole JL, Machen RL, et al. systemic acut-phase reactants CRP and haptoglobin, in adult periodontitis. Clin Exp Immunol. 1997 Feb, 107(2): 347-52.
17) Ellis J, Averley P, et al. changes in cardiovascular disease markers after dental clearance. Back to the periodontal Research program (April 5-April 7, 2005)
18) Farooqi QA, Grossi SG, et al. Effect of periodontal treatment on markers of systemic inflammation. Back to the periodontal research- therapy program. (March 10-13, 2004)
19) Faveri, M, Gursky LC, et al. Scaling and root-planing and chlorxidine mouthrinses in the treatment of chronic periodontitis: a randomized, placebo-controlled clinical trial. J clin perio 2006; 33: 819-28
20) Forner L, Neilson ch, et al. Increased plasma levels of IL6 in bacteremic periodontitis patients after scaling. J clin periodontal 2006; 33: 724-29.
21) Grossi S. et al. periodontal therapy . lowers levels of heart disease inflammation markers. American Den Assoc . 2004
22) Gustafsson A, Buhlin K, et al . Serological changes after periodontal treatment. Back to the periodontal research – diagnosis / epidemiology program (June 28-Jully 1, 2006)
23) Ide M, part lin MC, et al. Effect of treatment of chronic periodontitis on levels of serum markers of acute – phase inflammatory and vascular responses . J clin perio. 2003 Apr; 30:334
24) Ide M, Jagdev D, et al. The short – term effects of treatment of chronic periodotitis on circulating levels of endotoxin , CRP, tumor necrosis factor- and Il6. J periodontal . 2004 Mar; 75(3): 420-28.
25) Iwamato Y, Nishimura F, et al.Antimicroobial periodontal treatment decreases serum CRP, TNF But not adiponectin levels in patients with chronic periodontitis . J periodontal . 2003; 74 (8) : 1231-6
26) Kocher T, Schwahn C, et al. Association between periodontal disease and markers of systemic inflammation . Back to the periodontal research – Diagnosis/ epidemiology program (2002 March)
27) Loose BG, et al. systemic inflammatory markers in periodontitis. J Periodontal 2005; 76 (11) : 2106-14
28) Loos BG, Grandijk J, et al. Elevation of systemic markers related to cardiovascular disease in the peripheral blood of periodontitis patients .J periodonta 2000; 71(10) : 1528-34
29) Margareta IF, Carlose Ms, et al. Effect of periodontitis and smoking on blood leukocytes and acute – Phase proteins. J periodontal 1999 Nov; 70(11) : 1355-60
30) Mattila K, vesanen M, et al. Effect of treating periodontitis on CRP levels : a pilot study. BMC Infect Dis. 2002 Dec; 10(2) :30
31) Mongardini C, steenberghe DV, et al. One – stage full versus patient –mouth disinfection in the treatment of chronic adult or generalized early onset periodontitis. Jperiodontal. 1999 June ; 70(6): 632-45.
32) Mongradinic C, Qurynen M, et al. one – stage full versus patient –mouth disinfection in the treatment of chronic adult or genetalized early onset periodontitis. J periodontal. 1999 Jun; 70(6): 646-55.
33) Montebugnoli L, Servidio D, et al. Perdiodontal health improves inflammatory and haemostatic status in subjects with coronary heart disease. J clin perio 2005 Feb; 32: 188.
34) Noack B, Robert J, et al. periodontal infections contribute to elevated systemic CRP level. J periodontal 2001; 72(9) : 1221-27.
35) Quirynen M, Mongardin C, et al. The role of chlohexidine in the one-stage full-mouth disinfections treatment of patients with advanced adult periodontitis. J clin perio. 2000; 27: 578-89
36) Quirynen M, Bollen CM, Vanddekerckhove BN, et al. Full versus partial mouth disinfection in the treatment of periodontal infections: short term clinical and micrbiological observations. J Dent Res 1995; 77: 1459
37) Quirynen M, De soete M, Dierickx K, et al. The intra oral translocation of periodontopathogens Jeopadises the outcome of periodontal therapy: A reviw of the literature.
J clin periodontal 2001; 28:499
38) Radafshar G, Shad B, Mirfeizi MJ. Evaluation of periodontal disease relationship with elevated CRP in acute myocardial infarction .J of Dentistry Tehran university of medieal sciences. 2006; 3(3): 129-34.
39) Reynolds, Catherine K, et al. clinical effects of simultaneous ultrasonic scaling and dubging; val with chlorhexidine . J clin perio 1992 sep; 19 , Issue 8: 595-600
40) Ronald G, Yip JK, et al. Relationship of destructive periodontal disease to the acute phase response. J periodontal 2003 Jul; 74 (7) : 1007-16
41) Shah, Svati H M, et al. CRP: A Novel Marker of cardiovascular risk . cardiology in veview . 2003 July; 11 (4) : 169-79.
42) Soder PO, klinge B, et al. IL6, Fibrinogen, CRP and cholesterol in serum from subjects with aggressive periodontitis. Back to the periodontal research – pathogensis program (June 25-28,2003)
43) Taylor BA, Tofler Gh, et al. Eradication of periodontitis Alters levels of systemic markers and mediators. Back to the Scientific Groups program (Sep. 25-28, 2005)
44) Wang Y, Yang Ps, et al. Change of circulation TNFa in patients with advanced periodontitis before and after periodontal initial therapy. Shanghai kou Qiang Yi xue . 2003; 12 (2) : 85-7.
45) Yamazaki K, Honda T, et al. Effect of periodontal treatment on the CRP and proinflammatory cytokine levels in Japanese periodontitis patients. J perio Res. 2005 Feb; 40, Issue 1: 53
.